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CyFlow™ CD79b PerCP-Cy5.5

CyFlow™ CD79b PerCP-Cy5.5
Antigen: CD79b
Alternative Name: B29, IgB
Clone: CB3-1
Application: Flow cytometry
Format/Fluorochrome: PerCP-Cy5.5
Laser: Blue, Green
Target Species: Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 695 nm
Excitation Maximum: 482 nm
Isotype: IgG1
Order number: BH203025

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

HLDA Workshop HLDA VI—WS Code CD79.1 Quantity 100 tests Volume 0.4 Immunogen... more
CyFlow™ CD79b PerCP-Cy5.5
HLDA WorkshopHLDA VI—WS Code CD79.1
Quantity100 tests
ImmunogenFraction of Ig-associated molecules isolated from Ramos B cells
Background InformationCD79b (IgB, B29) forms disulfide-linked heterodimer with CD79a (IgA, MB-1, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with λ5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Nakamura T, Kubagawa H, Cooper MD: Heterogeneity of immunoglobulin‑associated molecules on human B cells identified by monoclonal antibodies. Proc·Natl·Acad·Sci·USA. 1992·Sep·15; 89(18):8522‑6. <·PMID:·1382292·> | Garcia Vela J, Delgado I, Benito L, Monteserin M, Garcia Alonso L, Somolinos N, Andreu M, Oña F: CD79b expression in B cell chronic lymphocytic leukemia: its implication for minimal residual disease detection. Leukemia. 1999·Oct; 13(10):1501‑5. <·PMID:·10516749·> | Rassenti LZ, Kipps TJ: Expression of Ig‑beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy‑chain allelic exclusion. Blood. 2000·Apr·15; 95(8):2725‑7. <·PMID:·10753858·> | D'Arena G, Cascavilla N, Musto P, Colella Bisogno R, Pistolese G, Carotenuto M: CD79b expression in B‑cell chronic lymphocytic leukemia. Haematologica. 2000·May; 85(5):556‑7. <·PMID:·10800181·> | Matutes E: New additions to antibody panels in the characterisation of chronic lymphoproliferative disorders. J·Clin·Pathol. 2002·Mar; 55(3):180‑3. <·PMID:·11896067·> | Dornan D, Bennett F, Chen Y, Dennis M, Eaton D, Elkins K, French D, Go MA, Jack A, Junutula JR, Koeppen H, Lau J, McBride J, Rawstron A, Shi X, Yu N, Yu SF, Yue P, Zheng B, Ebens A, Polson AG: Therapeutic potential of an anti‑CD79b antibody‑drug conjugate, anti‑CD79b‑vc‑MMAE, for the treatment of non‑Hodgkin lymphoma. Blood. 2009·Sep·24; 114(13):2721‑9. <·PMID:·19633198·> | Zheng B, Fuji RN, Elkins K, Yu SF, Fuh FK, Chuh J, Tan C, Hongo JA, Raab H, Kozak KR, Williams M, McDorman E, Eaton D, Ebens A, Polson AG: In vivo effects of targeting CD79b with antibodies and antibody‑drug conjugates. Mol·Cancer·Ther. 2009·Oct; 8(10):2937‑46. <·PMID:·19808977·>