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CyFlow™ CD61 APC-Cy7

CyFlow™ CD61 APC-Cy7
Antigen: CD61
Alternative Name: GPIIIa
Clone: VIPL2
Application: Flow cytometry
Format/Fluorochrome: APC-Cy7
Laser: Red
Target Species: Human, Non-Human Primates
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 780 nm
Excitation Maximum: 650 nm, 750 nm
Isotype: IgG1
Order number: CP539133

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

HLDA Workshop HLDA V—WS Code 5T-124 Quantity 100 tests Volume 0.4 Immunogen... more
CyFlow™ CD61 APC-Cy7
HLDA WorkshopHLDA V—WS Code 5T-124
Quantity100 tests
Immunogen< no data >
Background InformationCD61 (β3 integrin) is a transmembrane glycoprotein, which associates with CD41 or CD51 molecules to form heterodimeric adhesion receptores. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex has similar binding properties and is involved in modulating migration and survival of angiogenic endothelial cells.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, Buck DW, Schmitz J: BDCA‑2, BDCA‑3, and BDCA‑4: three markers for distinct subsets of dendritic cells in human peripheral blood. J·Immunol. 2000·Dec·1; 165(11):6037‑46. <·PMID:·11086035·> | Ciarlet M, Crawford SE, Cheng E, Blutt SE, Rice DA, Bergelson JM, Estes MK: VLA‑2 (alpha2beta{01} integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J·Virol. 2002·Feb; 76(3):1109‑23. <·PMID:·11773387·> | Roberts MS, Woods AJ, Dale TC, Van Der Sluijs P, Norman JC: Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins. Mol·Cell·Biol. 2004·Feb; 24(4):1505‑15. <·PMID:·14749368·> | Mondal D, Williams CA, Ali M, Eilers M, Agrawal KC: The HIV‑1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells. Exp·Biol·Med·(Maywood). 2005·Oct; 230(9):631‑44. <·PMID:·16179731·> | Williams CA, Mondal D, Agrawal KC: The HIV‑1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP. Exp·Biol·Med·(Maywood). 2005·Dec; 230(11):872‑84. <·PMID:·16339753·> | Barrett L, Dai C, Gamberg J, Gallant M, Grant M: Circulating CD14‑CD36+ peripheral blood mononuclear cells constitutively produce interleukin‑10. J·Leukoc·Biol. 2007·Jul; 82(1):152‑60. <·PMID:·17412916·>