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CyFlow™ CD3 PE-Cy5

CyFlow™ CD3 PE-Cy5
Application: Flow cytometry
Isotype: IgG1
Format/Fluorochrome: PE-Cy5
Target Species: Human, Non-Human Primates
Clone: UCHT1
Alternative Name: Leu4, T3
Antigen: CD3
Excitation Maximum: 496 nm, 565 nm
Clonality: monoclonal
Laser: Blue, Green, Yellow
Field of Interest: Immunophenotyping
Source Species: Mouse
Regulatory Status: RUO
Emission Maximum: 670 nm
Order number: BE142793
HLDA Workshop HLDA I—WS Code T 3 HLDA III—WS Code T 126 HLDA III—WS Code T 471 HLDA VI—WS... more
Product information "CyFlow™ CD3 PE-Cy5"
HLDA WorkshopHLDA I—WS Code T 3 HLDA III—WS Code T 126 HLDA III—WS Code T 471 HLDA VI—WS Code T 6T-CD3.1
Quantity100 tests
Volume0.4 mL
ImmunogenHuman thymocytes followed by Sezary T cells
Background InformationCD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3γ, CD3 δ, CD3ε and CD3ζ. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Technical Data Sheet

Certificate Of Analysis

ECDoC

Instruction for Use

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* All prices are quoted net of the statutory value-added tax and shipping costs and possibly delivery charges, if not otherwise described

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