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CyFlow™ CD79a Purified

CyFlow™ CD79a Purified
Antigen: CD79a
Alternative Name: IgA, MB-1, MB1
Clone: HM47
Application: Flow cytometry, Immunohistochmistry (paraffin-embedded sections), Immunoprecipitation, Western blot
Format/Fluorochrome: Purified
Target Species: Chicken, Cow, Dog, Guinea pig, Horse, Human, Mouse, Non-Human Primates, Pig, Rabbit, Rat
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: CM881146

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration 1 mg/ml Quantity 0.1 mg Volume 0.1 ml Immunogen Synthetic peptide... more
CyFlow™ CD79a Purified
Concentration1 mg/ml
Quantity0.1 mg
Volume0.1 ml
ImmunogenSynthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
SpecifityThe mouse monoclonal antibody HM57 recognizes CD79a, a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
Background InformationCD79a (Ig α, MB1) forms disulfide-linked heterodimer with CD79b (Ig β, B29). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with λ5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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