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CyFlow™ CD66e Purified

CyFlow™ CD66e Purified
Antigen: CD66e
Alternative Name: CEA
Clone: CB30
Application: Flow cytometry, Immunohistochemistry, Immunoprecipitation
Format/Fluorochrome: Purified
Target Species: Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: CU348583

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

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EUROBIOTECH2017

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*1 Offer valid until 23/09/2017
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 Immunogen... more
CyFlow™ CD66e Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1
ImmunogenHuman carcinoembryonic antigen (CEA; CEACAM5)
Background InformationCD66e (CEA) is a 180-200 kDa member of carcinoembryonic antigens, immunoglobulin supergene family and consists of a single N domain (structural homology to the immunoglobulin variable) and six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3). Human CD66e is heavily glycosylated GPI anchored protein capable of both homophilic and heterophilic adhesion. Disease relevance: The CD66e may play a role in the process of metastasis of cancer cells. CD66e is found in serum and it is clinically used as a tumor marker for early detection of disease due to its expression in adenocarcinomas - potential target of tumor imaging and drug targeting.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Oikawa S, Nakazato H, Kosaki G: Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. Biochem·Biophys·Res·Commun. 1987·Jan·30; 142(2):511‑8. <·PMID:·3814146·> | Thompson JA, Grunert F, Zimmermann W: Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J·Clin·Lab·Anal. 1991; 5(5):344‑66. <·PMID:·1941355·> | Chen CJ, Li LJ, Maruya A, Shively JE: In vitro and in vivo footprint analysis of the promoter of carcinoembryonic antigen in colon carcinoma cells: effects of interferon gamma treatment. Cancer·Res. 1995·Sep·1; 55(17):3873‑82. <·PMID:·7641207·> | Gangopadhyay A, Bajenova O, Kelly TM, Thomas P: Carcinoembryonic antigen induces cytokine expression in Kuppfer cells: implications for hepatic metastasis from colorectal cancer. Cancer·Res. 1996·Oct·15; 56(20):4805‑10. <·PMID:·8841002·>

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