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CyFlow™ CD63 Purified

CyFlow™ CD63 Purified
Antigen: CD63
Alternative Name: LAMP-3, LIMP, MLA1
Clone: MEM-259
Application: Flow cytometry, Immunocytochemistry, Immunohistochmistry (paraffin-embedded sections), Immunoprecipitation
Format/Fluorochrome: Purified
Target Species: Human
Field of Interest: Endocytosis, Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: BA410547

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration 1 mg/ml Quantity 0.1 mg Volume 0.1 ml Immunogen HPB-ALL T cell line... more
CyFlow™ CD63 Purified
Concentration1 mg/ml
Quantity0.1 mg
Volume0.1 ml
ImmunogenHPB-ALL T cell line
SpecifityThe mouse monoclonal antibody MEM-259 recognizes CD63 antigen, a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.
Background InformationCD63 (LAMP-3; lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. It is also present in the plasma membrane, usually following cell activation. Hence, it has become an widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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