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CyFlow™ CD44 PE

CyFlow™ CD44 PE
Antigen: CD44
Alternative Name: H-CAM, Pgp-1
Clone: MEM-263
Application: Flow cytometry
Format/Fluorochrome: PE
Laser: Blue, Green, Yellow
Target Species: Dog, Human, Pig
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Isotype: IgG1
Order number: BX574152

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

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Order 2, get the lower priced for free

*1
EUROBIOTECH2017

Order two antibodies and get the lower-priced one for free

*1 Offer valid until 23/09/2017
Quantity 100 tests Volume 2 Immunogen COS-7 African green monkey kidney cells... more
CyFlow™ CD44 PE
Quantity100 tests
Volume2
ImmunogenCOS-7 African green monkey kidney cells
Background InformationCD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumor growth and metastasis, antiapoptosis and directional motility of cancer cells.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 20·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| McMichael AJ, Beverley PCL, Cobbold S, et al (Eds): Leucocyte Typing III, White Cell Differentiation Antigens. Oxford·University·Press,·Oxford. 1987; 1‑1050. <·NLM·ID:·8913266·> | Liu J, Bi G, Wen P, Yang W, Ren X, Tang T, Xie C, Dong W, Jiang G: Down‑regulation of CD44 contributes to the differentiation of HL‑60 cells induced by ATRA or HMBA. Cell·Mol·Immunol. 2007·Feb; 4(1):59‑63. <·PMID:·17349212·> | Hollingsworth JW, Li Z, Brass DM, Garantziotis S, Timberlake SH, Kim A, Hossain I, Savani RC, Schwartz DA: CD44 regulates macrophage recruitment to the lung in lipopolysaccharide‑induced airway disease. Am·J·Respir·Cell·Mol·Biol. 2007·Aug; 37(2):248‑53. <·PMID:·17446529·> | Subramaniam V, Vincent IR, Gardner H, Chan E, Dhamko H, Jothy S: CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation. Exp·Mol·Pathol. 2007·Oct; 83(2):207‑15. <·PMID:·17599831·> | Subramaniam V, Gardner H, Jothy S: Soluble CD44 secretion contributes to the acquisition of aggressive tumor phenotype in human colon cancer cells. Exp·Mol·Pathol. 2007·Dec; 83(3):341‑6. <·PMID:·17945213·> | Vigetti D, Viola M, Karousou E, Rizzi M, Moretto P, Genasetti A, Clerici M, Hascall VC, De Luca G, Passi A: Hyaluronan‑CD44‑ERK1/2 regulate human aortic smooth muscle cell motility during aging. J·Biol·Chem. 2007·Dec·12; <·PMID:·20811967·>

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