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CyFlow™ CD42b PE

CyFlow™ CD42b PE
Antigen: CD42b
Alternative Name: GPIba
Clone: AK2
Application: Flow cytometry
Format/Fluorochrome: PE
Laser: Blue, Green, Yellow
Target Species: Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Isotype: IgG1
Order number: AE407501

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

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EUROBIOTECH2017

Order two antibodies and get the lower-priced one for free

*1 Offer valid until 23/09/2017
HLDA Workshop HLDA V—WS Code P024 Quantity 100 tests Volume 1 Immunogen Human... more
CyFlow™ CD42b PE
HLDA WorkshopHLDA V—WS Code P024
Quantity100 tests
Volume1
ImmunogenHuman platelets
Background InformationCD42b (GPIb α) composes together with GPIb β, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Vettore S, Scandellari R, Moro S, Lombardi AM, Scapin M, Randi ML, Fabris F: Novel point mutation in a leucine‑rich repeat of the GPIb alpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard‑Soulier syndrome affecting two unrelated families: the N41H variant. Haematologica. 2008·Nov; 93(11):1743‑7. <·PMID:·18815197·> | Welsh JD, Colace TV, Muthard RW, Stalker TJ, Brass LF, Diamond SL: Platelet‑targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse. J·Thromb·Haemost. 2012·Nov; 10(11):2344‑53. <·PMID:·22978514·>

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