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CyFlow™ CD21 PE-Cy5

CyFlow™ CD21 PE-Cy5
Antigen: CD21
Alternative Name: C3dR, CR2, EBV-R
Clone: LT21
Application: Flow cytometry
Format/Fluorochrome: PE-Cy5
Laser: Blue, Green, Yellow
Target Species: Cow, Dog, Human, Pig
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 670 nm
Excitation Maximum: 496 nm, 565 nm
Isotype: IgG1
Order number: AW460934

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Quantity 100 tests Volume 0.4 ml Immunogen IM9 human B-lymphoblastoid cell line... more
CyFlow™ CD21 PE-Cy5
Quantity100 tests
Volume0.4 ml
ImmunogenIM9 human B-lymphoblastoid cell line
SpecifityThe mouse monoclonal antibody LT21 recognizes CD21 antigen, a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells.
Background InformationCD21 (CR2; complement receptor 2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.