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CyFlow™ CD8a Purified

CyFlow™ CD8a Purified
Antigen: CD8a
Alternative Name: Leu2, T8
Clone: OX-8
Application: Flow cytometry, Functional assays, Immunohistochemistry, Immunoprecipitation, Western blot
Format/Fluorochrome: Purified
Target Species: Rat
Field of Interest: Immunophenotyping, MHC
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Isotype: IgG1
Order number: CV104204

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration 1 mg/ml Quantity 0.1 mg Volume 0.1 ml Immunogen High Mw... more
CyFlow™ CD8a Purified
Concentration1 mg/ml
Quantity0.1 mg
Volume0.1 ml
ImmunogenHigh Mw glycoproteins from rat thymocytes
SpecifityThe mouse monoclonal antibody OX-8 recognizes the hinge-like membrane-proximal domain of rat CD8a, a 32-34 kDa α chain of the CD8 antigen.
Background InformationThe CD8a (CD8 α) subunit of CD8 T cell coreceptor is expressed in CD8 α/β heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 α/α homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 α/β but not α/α dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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