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CyFlow™ CD3 FITC

CyFlow™ CD3 FITC
Antigen: CD3
Alternative Name: Leu4, T3
Clone: 145-2C11
Application: Flow cytometry
Format/Fluorochrome: FITC
Laser: Blue
Target Species: Mouse
Field of Interest: Immunophenotyping, MHC
Species of Origin: Hamster
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 518 nm
Excitation Maximum: 490 to 495 nm
Isotype: IgG
Order number: AJ219456

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

Concentration 0.5 mg/ml Quantity 0.1 mg Volume 0.2 ml Immunogen Mouse BM10-37... more
CyFlow™ CD3 FITC
Concentration0.5 mg/ml
Quantity0.1 mg
Volume0.2 ml
ImmunogenMouse BM10-37 cytotoxic T lymphocytes
SpecifityThe Armenian hamster monoclonal antibody 145-2C11 recognizes mouse CD3 (ε subunit). This antibody is commonly used as a phenotypic marker for mouse T cells.
Background InformationCD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3γ, CD3 δ, CD3ε and CD3ζ. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
UsageThe reagent is designed for Flow Cytometry analysis. Suggested working usage is 2·µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

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